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Update on Predicting Severe Hyperbilirubinemia and Bilirubin Neurotoxicity Risks in Neonates

[ Vol. 13 , Issue. 3 ]


Pearl W. Chang*, Thomas B. Newman and M. Jeffrey Maisels   Pages 181 - 187 ( 7 )


Extreme hyperbilirubinemia and kernicterus, though rare, continue to occur despite the adoption of universal screening. Unless they are known to have glucose-6-phosphate dehydrogenase deficiency, infants who currently develop kernicterus in high resource countries are often otherwise healthy newborns discharged from the well-baby nursery. In this review, we highlight risk factors that increase the risk of a newborn ≥35 weeks gestational age developing severe hyperbilirubinemia, as well as the risk factors that increase the hyperbilirubinemic infant’s risk of kernicterus.


Hyperbilirubinemia, jaundice, neonates, kernicterus, neurotoxicity, phototherapy.


Seattle Children’s Hospital, M/S FA.2.115, PO Box 5371, Seattle, WA 98145, Departments of Epidemiology & Biostatistics and Pediatrics, University of California, San Francisco, CA, Department of Pediatrics, Beaumont Children’s Hospital and Oakland University William Beaumont School of Medicine, Royal Oak, MI

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