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Is Pouch Specific to Colon and Not Ileum?

Author(s):

Sonal Gupta, Pradeep Tiwari, Nidhi Gupta, Vandana Nunia, Amulya K Saxena, Anita Simlot, Shanker Lal Kothari, Prashanth Suravajhala*, Krishna Mohan Medicherla and Praveen Mathur   Pages 1 - 6 ( 6 )

Abstract:


Background: Congenital Pouch Colon (CPC) is an anorectal anomaly with an incidence of 3.5:1 in males and females, respectively. We have earlier reported CPC to be quite prevalent in north Indian tertiary care centers.

Objective: In this article, we deliberate on the possible causes associated with CPC bringing the manifestation of the disease. In addition, we throw insights on the effective role of this congenital anomaly in Colon and provide systems genomic evaluation by comparing our recent analysis to that of Colon and Ileum based on next-generation sequencing (NGS) studies.

Conclusion: In this commentary article, we argue that a host of epigenetic factors could be the reason why the disease is manifested in colon alone. We further hypothesize on the few unmet challenges linking epigenetics to understand the genetic variants.

Keywords:

Congenital pouch colon, anorectal malformation, colovesical fistula, colostomy, imperforate anus, genomics

Affiliation:

Department of Biotechnology and Bioinformatics, Birla Institute of Scientific Research, Jaipur 302001, RJ, Department of Chemistry, School of Basic Sciences, Manipal University Jaipur, Jaipur 303007, RJ, Department of Biotechnology, The IIS University, Mansarovar, Jaipur 302020, Department of Zoology, University of Rajasthan, Jaipur 302004, RJ, Department of Pediatric Surgery, Imperial College London, Department of Obstretrics and Gynaecology, SMS Medical College, JLN Marg, Jaipur 302004 RJ, Department of Biotechnology, Amity University Rajasthan, Jaipur 303002 RJ, Department of Biotechnology and Bioinformatics, Birla Institute of Scientific Research, Jaipur 302001, RJ, Department of Biotechnology and Bioinformatics, Birla Institute of Scientific Research, Jaipur 302001, RJ, Department of Pediatric Surgery, SMS Medical College, JLN Marg, Jaipur 302004 RJ



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