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COVID-19 and Comorbidities: Is Inflammation the Underlying Condition in Children? A Narrative Review

[ Vol. 17 , Issue. 1 ]

Author(s):

Giulia Pinna, Lavinia Sanfilippo, Pier Paolo Bassareo*, Vassilios Fanos and Maria Antonietta Marcialis   Pages 38 - 44 ( 7 )

Abstract:


This paper examines the potential link between COVID-19 and the presence of comorbidities and assesses the role of inflammation in this correlation. In COVID-19 patients, the most frequently associated diseases share a pathogenic inflammatory basis and apparently act as a risk factor in the onset of a more severe form of the disease, particularly in adulthood. However, in children, the understanding of the underlying pathogenic mechanisms is often complicated by the milder symptoms presented. A series of theories have, therefore, been put forward with a view of providing a better understanding of the role played by inflammation in this dramatic setting. All evidence available to date on this topic is discussed in this review.

Keywords:

COVID-19, coronavirus, inflammation, risk factors, children, pathogenic.

Affiliation:

Neonatal Intensive Care Unit, University of Cagliari, Cagliari, Neonatal Intensive Care Unit, University of Cagliari, Cagliari, University College of Dublin, Mater Misericordiae University Hospital and Our Lady’s Children’s Hospital Crumlin, Dublin, Neonatal Intensive Care Unit, University of Cagliari, Cagliari, Neonatal Intensive Care Unit, University of Cagliari, Cagliari



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